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LGD 4033 , also known as Ligandrol or Anabolicum, is an oral SARM compound that is used to gain muscle mass and prevent muscle wastagein the body during physical activity. The compound is currently being used in clinical studies to increase the lean muscle mass in older adults with limited muscle mass.In this study, we evaluated the ability of ALCAR-D-33 to increase circulating concentrations of L-[ring-13C 6 ]tyrosine (LTB), a marker of muscle protein breakdown, in older adults who were pre- or post-randomized to either a placebo or 10mg daily dose of Ligandrol.The primary efficacy and safety endpoint of this study was change in circulating LTB concentrations after eight weeks of treatment. Secondary efficacy and safety outcomes include change in LTB concentrations to a normal value, changes in resting energy expenditure (REE) to a normal value, and improvements in muscle strength (M) score. The primary data analysis and key secondary analyses were based on a randomized, double-blind, placebo-controlled, crossover study design that included 15 subjects. Data were submitted to the Center for the Coordination of Clinical Trials of the National Health and Social Sciences Canada (NHSSC) and a second blinded analysis of data was completed. Inclusion criteria were normal or corrected mean difference (MMD) ± standard deviation (SD) in LTB concentrations before and after eight weeks of treatment. Exclusion criteria included: (1) being on lipid lowering therapy or any other medications, (2) being older than 65 years of age, (3) being female or of the opposite sex; (4) any history of cardiovascular disease or diabetes; (5) any history of stroke or heart disease; (6) chronic kidney disease or dialysis; (7) using drugs that could negatively affect LTB absorption or metabolism; (8) previous drug interaction with or within the drug compound, (9) current use of another SARM with or without Ligandrol, and (10) current use of any medications that might affect blood pressure or cholesterol levels. Subjects were also excluded if they had any known cardiac, neurological disorder, brain tumor, or brain biopsy results. After initial eligibility, subjects had to have LTB concentration of at least 0.8 ng/mL or a fasting plasma amino acid level of less than 2.5 mg/dL within 6 hours of the time of randomization. Subjects were instructed to refrain from any strenuous physical exercise for at least 24 hours immediately prior to the commencement of the LTB measurement and to undergo daily blood sampling until LTB concentrations were within the predetermined range.ParticipantsSimilar articles: